EFFECTS OF THE AURORA KINASE INHIBITORS AZD1152-HQPA AND ZM447439 ON GROWTH ARREST AND POLYPLOIDY IN ACUTE MYELOID LEUKEMIA CELL LINES AND PRIMARY BLASTS

Background Aurora kinases play an essential role in the orchestration of chromosome separation and cytokinesis during mitosis.Small-molecule inhibition of the aurora kinases has been shown to result in inhibition of cell division, phosphorylation of histone H3 and the induction of apoptosis in a number of cell systems.These characteristics have led

The aim of this work was to develop a process for the removal of Sn, Sb and As from anode slime out of Shaft copper refinery to disburden a subsequent pyrometallurgical processing for precious metals refinement.For this reason, a detailed literature survey was conducted, followed by a characterization to find the present compounds/alloys and their

Type 2 diabetes mellitus (T2DM) patients are highly susceptible to developing dementia, especially for those with mild cognitive impairment (MCI), but its underlying cause is still unclear.In this study, we performed a battery of neuropsychological tests and high-resolution sagittal T1-weighted structural imaging to explore how T2DM affects white m

Erectile dysfunction is the inability to achieve or sustain a penile erection for vaginal penetration and satisfactory sexual performance.It is the second most frequent problem of sexual dysfunction in men, after premature Tatami Cushion ejaculation, with an approximate prevalence rate of 30%.Most cases of erectile dysfunction have an organic origi

The renewed conflict between Russia and NATO has brought back security concerns over nuclear and conventional deterrence and defence in Europe.Since the days of the Cold War those two elements are closely intertwined, with direct ramifications on arms control policies.This article recalls the post-Cold War history of conventional arms control in Eu